miR-34a targets PAI-1 to regulate urinary microalbumin and renal function in hypertensive mice
نویسندگان
چکیده
منابع مشابه
miR‐34a−/− mice are susceptible to diet‐induced obesity
OBJECTIVE MicroRNA (miR)-34a regulates inflammatory pathways, and increased transcripts have been observed in serum and subcutaneous adipose of subjects who have obesity and type 2 diabetes. Therefore, the role of miR-34a in adipose tissue inflammation and lipid metabolism in murine diet-induced obesity was investigated. METHODS Wild-type (WT) and miR-34a(-/-) mice were fed chow or high-fat d...
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The roles of long non-coding RNAs (lncRNAs) in regulating cancer and stem cells are being increasingly appreciated. Its diverse mechanisms provide the regulatory network with a bigger repertoire to increase complexity. Here we report a novel LncRNA, Lnc34a, that is enriched in colon cancer stem cells (CCSCs) and initiates asymmetric division by directly targeting the microRNA miR-34a to cause i...
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Nutlin-3, an MDM2 inhibitor, activates p53, resulting in several types of cancer cells undergoing apoptosis. Although p53 is mutated or deleted in approximately 50% of all cancers, p53 is still functionally active in the other 50%. Consequently, nutlin-3 and similar drugs could be candidates for neoadjuvant therapy in cancers with a functional p53. Cellular senescence is also a phenotype induce...
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Hypertension is one of the major risk factor for an increased risk of stroke, myocardial infarction, end-stage renal disease, congestive heart failure and peripheral vascular disease. The kidney is a main target of organ damage in hypertension. Microalbuminuria is one of the earliest indications of kidney injury in patients with hypertension. Total of 50 cases and 50 controls are enrolled into ...
متن کاملMicro(mi) RNA-34a targets protein phosphatase (PP)1γ to regulate DNA damage tolerance
The DNA damage response (DDR) triggers widespread changes in gene expression, mediated partly by alterations in micro(mi) RNA levels, whose nature and significance remain uncertain. Here, we report that miR-34a, which is upregulated during the DDR, modulates the expression of protein phosphatase 1γ (PP1γ) to regulate cellular tolerance to DNA damage. Multiple bio-informatic algorithms predict t...
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ژورنال
عنوان ژورنال: European Journal of Medical Research
سال: 2020
ISSN: 2047-783X
DOI: 10.1186/s40001-020-00404-7